Characterization of two cases of bullous pemphigoid reactive only with BP230 on Japanese enzyme-linked immunosorbent assays.
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چکیده
منابع مشابه
Usefulness of Enzyme-linked Immunosorbent Assay Using Recombinant BP180 and BP230 for Serodiagnosis and Monitoring Disease Activity of Bullous Pemphigoid
BACKGROUND Bullous pemphigoid (BP) is an autoimmune subepidermal bullous disease associated with autoantibodies against BP180 and BP230. Enzyme-linked immunosorbent assay (ELISA) is a sensitive tool for the detection of immunoglobulin G (IgG) anti-BP180 and anti-BP230 autoantibodies. OBJECTIVE The aim of this study was to evaluate the usefulness of ELISA for diagnosing and monitoring the dise...
متن کاملUsefulness of BP230 and BP180-NC16a enzyme-linked immunosorbent assays in the initial diagnosis of bullous pemphigoid: a retrospective study of 138 patients.
OBJECTIVE To investigate the diagnostic value of commercially available BP230 and BP180-NC16a enzyme-linked immunosorbent assays (ELISAs) in routine practice in patients with bullous pemphigoid (BP). DESIGN Single-center retrospective study. SETTING French academic dermatology department. PATIENTS The study population comprised 138 patients, who were admitted from January 1998 through Dec...
متن کاملAccuracy of molecular diagnostics in pemphigus and bullous pemphigoid: comparison of commercial and modified mosaic indirect immunofluorescence tests as well as enzyme-linked immunosorbent assays
INTRODUCTION Pemphigus and bullous pemphigoid (BP) are identified by autoantibodies (abs) against desmoglein 1, 3 (DSG1/3) and BP180/BP230, respectively. A novel mosaic to indirect immunofluorescence (IIF) using purified BP180 recombinant proteins spotted on slide and transfected cells expressing BP230, DSG1, DSG3 is available. The commercial (IgG detection) and modified (IgG4 detection) mosaic...
متن کاملAnti-bullous pemphigoid 180 and 230 antibodies in a sample of unaffected subjects.
OBJECTIVE To evaluate the prevalence of autoantibodies against 2 hemidesmosomal proteins typically found in patients with bullous pemphigoid (BP), BP antigen II (BP180) and BP antigen I (BP230), in persons without BP. DESIGN Cross-sectional study. SETTING Academic medical center. Patients An age- and sex-stratified, random, population-based sample of local county patients seen during 2007: ...
متن کاملIgE autoreactivity in bullous pemphigoid: eosinophils and mast cells as major targets of pathogenic immune reactants†
BACKGROUND Bullous pemphigoid (BP) is an autoimmune disease characterized by tense blisters that are usually preceded by urticarial eruptions. Affected patients exhibit IgG and/or IgE autoantibodies against BP180 and/or BP230. Their relative importance in disease pathogenesis has not been fully elucidated. OBJECTIVES The aim of this study was to provide a better characterization of the circul...
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عنوان ژورنال:
- Acta dermato-venereologica
دوره 94 6 شماره
صفحات -
تاریخ انتشار 2014